We developed a mathematical model of blood gas exchange and transport of oxygen and carbon dioxide. The respiratory system could simulate physiological and pathological conditions with multiple lung compartments featuring dedicated ventilation-perfusion ratios.
The model could also simulate a veno-venous extracorporeal membrane oxygenation (vv-ECMO) support.
The model computes the partial pressures of O₂ and CO₂ in different body districts.
In the Body (O2) page, you can modify the independent variables affecting oxygenation and see, in real time, changes in partial pressure of oxygen (PO₂) and hemoglobin saturation (SatO₂) of different circulatory districts.
In the Plotter (O2) page, you can create multiple line plots combining all the available input and output variables. A file with the plot data could be downloaded following login.
In the Simulator (O2 + CO2) page,you can evaluate the role of the main independent parameters affecting oxygenation and carbon dioxide elimination on the trend over time of many variables, including arterial PO₂ and PCO₂ . Login is required to start the simulation.
You can use this model as a teaching tool and a decision-making aid for physicians. Interestingly, when the extracorporeal blood flow is set to zero, the model simulates the physiology of oxygen delivery in patients not supported by vv-ECMO.
For further insight in the model, please read the following manuscript: A mathematical model of oxygenation during venovenous extracorporeal membrane oxygenation support. Zanella A, Salerno D, Scaravilli V, Giani M, Castagna L, Magni F, Carlesso E, Cadringher P, Bombino M, Grasselli G, Patroniti N, Pesenti A. J Crit Care. 2016 Dec;36:178-186. doi: 10.1016/j.jcrc.2016.07.008. Epub 2016 Jul 15. PMID: 27546769